Kenneth D. Aiello is a postdoctoral research scholar with the Global BioSocial Complexity Initiative at ASU. Kenneth’s research contributes to cross disciplinary conversations on how historical developments in biological, social, and cultural knowledge systems are governed by processes that transform the structure, dynamics, and function of complex systems. Applying computational historical analysis and epistemology to question what scientific knowledge is and how we can analyze changes in knowledge, he uses text analysis, social network analysis, and machine learning to measure similarities and differences between the knowledge claims of individual agents and groups. His work builds on how to assess contested knowledge claims and measure the evolution of knowledge across complex systems and multiple dimensions of scale. This approach also engages in dynamic new debates about global and local structures of knowledge shaped by technological innovation within microbiology related to public policy, shrinking resources given to biomedical ideas as opposed to “translation”, and the ethics of scientific discovery. Using interdisciplinary methods for understanding historical content and context rich narratives contributes to understanding new domains and major transitions in science and provides a richer understanding of how knowledge emerges.