Identifying how organisms respond to environmental stressors remains of central importance as human impacts continue to shift the environmental conditions for countless species. Some mammals are able to mitigate these environmental stressors at the cellular level, but the mechanisms by which cells are able to do this and how these strategies vary among species is not well understood. At the cellular level, it is difficult to identify the temporal dynamics of the system through empirical data because fine-grained time course samples are both incomplete and limited by available resources. To help identify the mechanisms by which animal cells mitigate extreme environmental conditions, we propose an agent-based model to capture the dynamics of the system. In the model, agents are regulatory elements and genes, and are able to impact the behaviors of each other. Rather than imposing rules for these interactions among agents, we will begin with randomized sets of rules and calibrate the model based on empirical data of cellular responses to stress. We will apply a common-garden framework to cultured cells from 16 mammalian species, which will yield genomic data and measures of cell morphology and physiology when exposed to different levels of temperature, glucose, and oxygen. These species include humans, dolphins, bats, and camels, among others, which vary in how they respond to environmental stressors, offering a comparative approach for identifying mechanistic rules whereby cells achieve robustness to environmental stressors. For calibration of the model, we will iteratively select for rules that best lead to the emergent outcomes observed in the cellular assays. Our model is generalized for any species, any cell type, and any environmental stressor, offering many applications of the model beyond our study. This study will increase our understanding of how organisms mitigate environmental stressors at the cellular level such that we can better address how organisms are impacted by and respond to extreme environmental conditions.

SeaROOTS ABM is a quite generic agent-based modeling system, for simulating and evaluating potential terrestrial and maritime mobility of artificial hominin groups, configured by available archaeological data and hypotheses. Necessary bathymetric, geomorphological and paleoenvironmental data are combined in order to reconstruct paleoshorelines for the study area and produce an archaeologically significant agent environment. Paleoclimatic and archaeological data are incorporated in the ABM in order to simulate maritime crossings and assess the emergent patterns of interaction between human agency and the sea.

SeaROOTS agent-based system includes completely autonomous, utility-based agents (Chliaoutakis & Chalkiadakis 2016), representing artificial hominin groups, with partial knowledge of their environment, for simulating their evolution and potential maritime mobility, utilizing alternative Least Cost Path analysis modeling techniques (Gustas & Supernant 2017, Gravel-Miguel & Wren 2021). Two groups of hominins, Neanderthals and Homo sapiens, are chosen in order to study the challenges and actions employed as a response to the fluctuating sea-levels, as well as probability scenarios with respect to sea-crossings via buoyant vessels (rafting) or the human body itself (swimming). SeaROOTS ABM aims to simulate various scenarios and investigate the degree climatic fluctuations influenced such activities and interactions in the Middle Paleolithic period.

The model focuses on simulating potential terrestrial and maritime routes, explore the interactions and relations between autonomous agents and their environment, as well as to test specific research questions; for example, when and under what conditions would Middle Paleolithic hominins be more likely to attempt a crossing and successfully reach the islands? By which agent type (Sapiens or Neanderthals) and how (e.g. swimming or by sea-vessels) could such short sea crossings be (mostly) attempted, and which (sea) routes were usually considered by the agents? When does a sea-crossing become a choice and when is it a result of forced migration, i.e. disaster- or conflict-induced displacement? Results show that the dynamic marine environment of the Inner Ionian, our case study in this work, played an important role in their decision-making process.

Overview

Purpose

Modeling an economy with stable macro signals, that works as a benchmark for studying the effects of the agent activities, e.g. extortion, at the service of the elaboration of public policies..
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This model is an agent-based simulation written in Python 2.7, which simulates the cost of social care in an ageing UK population. The simulation incorporates processes of population change which affect the demand for and supply of social care, including health status, partnership formation, fertility and mortality. Fertility and mortality rates are drawn from UK population data, then projected forward to 2050 using the methods developed by Lee and Carter 1992.

The model demonstrates that rising life expectancy combined with lower birthrates leads to growing social care costs across the population. More surprisingly, the model shows that the oft-proposed intervention of raising the retirement age has limited utility; some reductions in costs are attained initially, but these reductions taper off beyond age 70. Subsequent work has enhanced and extended this model by adding more detail to agent behaviours and familial relationships.

The version of the model provided here produces outputs in a format compatible with the GEM-SA uncertainty quantification software by Kennedy and O’Hagan. This allows sensitivity analyses to be performed using Gaussian Process Emulation.

This model is an extended version of the original MERCURY model (https://www.comses.net/codebases/4347/releases/1.1.0/ ) . It allows for experiments to be performed in which empirically informed population sizes of sites are included, that allow for the scaling of the number of tableware traders with the population of settlements, and for hypothesised production centres of four tablewares to be used in experiments.

Experiments performed with this population extension and substantive interpretations derived from them are published in:

Hanson, J.W. & T. Brughmans. In press. Settlement scale and economic networks in the Roman Empire, in T. Brughmans & A.I. Wilson (ed.) Simulating Roman Economies. Theories, Methods and Computational Models. Oxford: Oxford University Press.

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WeDiG Sim- Weighted Directed Graph Simulator - is an open source application that serves to simulate complex systems. WeDiG Sim reflects the behaviors of those complex systems that put stress on scale-free, weightedness, and directedness. It has been implemented based on “WeDiG model” that is newly presented in this domain. The WeDiG model can be seen as a generalized version of “Barabási-Albert (BA) model”. WeDiG not only deals with weighed directed systems, but also it can handle the […]

This model was designed to study resilience in organizations. Inspired by ethnographic work, it follows the simple goal to understand whether team structure affects the way in which tasks are performed. In so doing, it compares the ‘hybrid’ data-inspired structure with three more traditional structures (i.e. hierarchy, flexible/relaxed hierarchy, and anarchy/disorganization).

ViSA 2.0.0 is an updated version of ViSA 1.0.0 aiming at integrating empirical data of a new use case that is much smaller than in the first version to include field scale analysis. Further, the code of the model is simplified to make the model easier and faster. Some features from the previous version have been removed.
It simulates decision behaviors of different stakeholders showing demands for ecosystem services (ESS) in agricultural landscape. It investigates conditions and scenarios that can increase the supply of ecosystem services while keeping the viability of the social system by suggesting different mixes of initial unit utilities and decision rules.

ViSA simulates the decision behaviors of different stakeholders showing demands for ecosystem services (ESS) in agricultural landscape. The lack of sufficient supply of ESSs triggers stakeholders to apply different management options to increase their supply. However, while attempting to reduce the supply-demand gap, conflicts arise among stakeholders due to the tradeoff nature of some ESS. ViSA investigates conditions and scenarios that can minimize such supply-demand gap while reducing the risk of conflicts by suggesting different mixes of management options and decision rules.

The NIER model is intended to add qualitative variables of building owner types and peer group scales to existing energy efficiency retrofit adoption models. The model was developed through a combined methodology with qualitative research, which included interviews with key stakeholders in Cleveland, Ohio and Detroit and Grand Rapids, Michigan. The concepts that the NIER model adds to traditional economic feasibility studies of energy retrofit decision-making are differences in building owner types (reflecting strategies for managing buildings) and peer group scale (neighborhoods of various sizes and large-scale Districts). Insights from the NIER model include: large peer group comparisons can quickly raise the average energy efficiency values of Leader and Conformist building owner types, but leave Stigma-avoider owner types as unmotivated to retrofit; policy interventions such as upgrading buildings to energy-related codes at the point of sale can motivate retrofits among the lowest efficient buildings, which are predominantly represented by the Stigma-avoider type of owner; small neighborhood peer groups can successfully amplify normal retrofit incentives.