The Holmestrand model is an epidemiological agent-based model. Its aim is to test hypotheses related to how the social and physical environment of a residential school for children with disabilities might influence the spread of an infectious disease epidemic among students and staff. Annual reports for the Holmestrand School for the Deaf (Norway) are the primary sources of inspiration for the modeled school, with additional insights drawn from other archival records for schools for children with disabilities in early 20th century Norway and data sources for the 1918 influenza pandemic. The model environment consists of a simplified boarding school that includes residential spaces for students and staff, classrooms, a dining room, common room, and an outdoor area. Students and staff engage in activities reflecting hourly schedules suggested by school reports. By default, a random staff member is selected as the first case and is infected with disease. Subsequent transmission is determined by agent movement and interactions between susceptible and infectious pairs.

EMMIT is an end-user developed agent-based simulation of malaria transmission. The simulation’s development is a case study demonstrating an approach for non-technical investigators to easily develop useful simulations of complex public health problems. We focused on malaria transmission, a major global public health problem, and insecticide resistance (IR), a major problem affecting malaria control. Insecticides are used to reduce transmission of malaria caused by the Plasmodium parasite that is spread by the Anopheles mosquito. However, the emergence and spread of IR in a mosquito population can diminish the insecticide’s effectiveness. IR results from mutations that produce behavioral changes or biochemical changes (such as detoxification enhancement, target site alterations) in the mosquito population that provide resistance to the insecticide. Evolutionary selection for the IR traits reduces the effectiveness of an insecticide favoring the resistant mosquito population. It has been suggested that biopesticides, and specifically those that are Late Life Acting (LLA), could address this problem. LLA insecticides exploit Plasmodium’s approximate 10-day extrinsic incubation period in the mosquito vector, a delay that limits malaria transmission to older infected mosquitoes. Since the proposed LLA insecticide delays mosquito death until after the exposed mosquito has a chance to produce several broods of offspring, reducing the selective pressure for resistance, it delays IR development and gives the insecticide longer effectivity. Such insecticides are designed to slow the evolution of IR thus maintaining their effectiveness for malaria control. For the IR problem, EMMIT shows that an LLA insecticide could work as intended, but its operational characteristics are critical, primarily the mean-time-to-death after exposure and the associated standard deviation. We also demonstrate the simulation’s extensibility to other malaria control measures, including larval source control and policies to mitigate the spread of IR. The simulation was developed using NetLogo as a case study of a simple but useful approach to public health research.

This model is an abstract simulation of the COVID-19 virus in the United States population. It demonstrates how different masks of different types affect the progress of the virus.

The Mission San Diego model is an epidemiological model designed to test hypotheses related to the spread of the 1805-1806 measles epidemic among indigenous residents of Mission San Diego during the early mission period in Alta California. The model community is based on the population of the Mission San Diego community, as listed in the parish documents (baptismal, marriage, and death records). Model agents are placed on a map-like grid that consists of houses, the mission church, a women’s dormitory (monjeria) adjacent to the church, a communal kitchen, priest’s quarters, and agricultural fields. They engage in daily activities that reflect known ethnographic patterns of behavior at the mission. A pathogen is introduced into the community and then it spreads throughout the population as a consequence of individual agent movements and interactions.

The St Anthony flu model is an epidemiological model designed to test hypotheses related to the spread of the 1918 influenza pandemic among residents of a small fishing community in Newfoundland and Labrador. The 1921 census data from Newfoundland and Labrador are used to ensure a realistic model population; the community of St. Anthony, NL, located on the tip of the Northern Peninsula of the island of Newfoundland is the specific population modeled. Model agents are placed on a map-like grid that consists of houses, two churches, a school, an orphanage, a hospital, and several boats. They engage in daily activities that reflect known ethnographic patterns of behavior in St. Anthony and other similar communities. A pathogen is introduced into the community and then it spreads throughout the population as a consequence of individual agent movements and interactions.